The implementation of digital point-of-care diagnostics for febrile illnesses in African healthcare facilities heavily relies on the readiness of healthcare systems and the trust of both clinicians and patients, rather than solely on the performance of the diagnostic technologies themselves. A realist review, led by Shola Molemodile Dele-Olowu with an international team including researchers from the University of Ghana and the London School of Hygiene and Tropical Medicine, emphasizes that diagnostic tools must be integrated within complex socio-technical systems to be effective, especially in resource-limited settings.
Febrile illnesses, which include malaria, typhoid fever, and dengue, represent a prevalent reason for medical consultations across various African nations. Traditionally, primary healthcare providers have resorted to symptom-based treatments due to significant diagnostic deficiencies, leading to inappropriate treatment and contributing to increased patient morbidity and antimicrobial resistance. Although advancements in diagnostic tests have shown potential, their adoption has been inconsistent across different health systems.
The recent review sought to understand how systemic readiness influences the success or failure of integrating these digital diagnostic tools. Employing a theory-driven approach, the researchers analyzed various contexts in which these technologies operate and identified the conditions necessary for their effective implementation.
The study examined literature published between 2005 and 2025, employing both systematic searches and expert consultations. The researchers narrowed an initial pool of 2,093 records to 17 pertinent papers after filtering for quality and relevance. Most studies were published in the past decade, reflecting a growing academic interest in digital health integration, particularly in South Africa and other regions of sub-Saharan Africa.
Five core elements were identified as crucial for health system readiness: device usability, workforce competence, digital infrastructure reliability, governance alignment, and the ability to leverage data for decision-making. For instance, user-friendly devices that fit seamlessly into clinical workflows were shown to enhance clinician confidence, while inadequate staffing and infrastructure often led to distrust and abandonment of digital platforms.
The researchers also noted that when digital health technologies are officially recognized and incorporated into clinical guidelines by public health ministries, clinicians are more likely to utilize them. Conversely, fragmented procurement processes and lack of training can severely hinder adoption, causing healthcare workers to revert to traditional symptom-based treatment methods.
Overall, the findings of the review indicate that integrating digital diagnostics into healthcare systems in Africa requires substantial investment in various institutional capacities and support mechanisms. Future research is recommended to explore the long-term impact of these technologies beyond pilot projects supported by external funding.


