The Week 5 NFL schedule features several key matchups, including the Chicago Bears facing off against the Green Bay Packers and the San Francisco 49ers squaring off against the Seattle Seahawks. These games lead into a highly anticipated Monday Night Football encounter between the Buffalo Bills and the Los Angeles Rams. As the 2026 NFL season approaches its unofficial quarter mark, experts from SportsLine are providing insights and betting advice based on the latest statistics and trends.
The latest odds place the Bears as 2.5-point favorites over the Packers, while the Rams are 3-point favorites against the Bills. The game between the Rams and Bills carries an over/under of 54.5 points, which is the highest for the Week 5 slate.
For those seeking expert betting predictions, key matchups on Sunday, October 11, include:
Week 5 NFL Picks
Eagles vs. Jaguars, 9:30 a.m. ET from London
Pick: Eagles Under 17.5 total team points
R.J. White notes that the Eagles are facing challenges with injuries, making the Jaguars’ strong defense a tough matchup. Given their recent struggles on offense, particularly in a game where they managed only 172 yards despite putting up 20 points, the prediction is for the Eagles to struggle to reach 17.5 points.
Bears vs. Packers, 1 p.m. ET
Pick: Bears (-2.5)
According to David Bearman, the Bears lead the NFL in total yards and rushing while also ranking high in time of possession. Their defense has improved significantly since Week 1, allowing only 28 points over their subsequent games, which positions them favorably against the Packers.
Texans vs. Titans, 1 p.m. ET
Pick: Titans (+7.5)
Jeff Hochman points to the Titans’ solid offensive line, which has allowed only six sacks this season, contrasting with the Texans’ struggles. Considering potential weather conditions, Hochman believes the Titans can exceed expectations as home underdogs.
Raiders vs. Patriots, 1 p.m. ET
Pick: Raiders (+3.5)
R.J. White highlights the Raiders’ potential following a recent competitive performance against a quality opponent, while expressing skepticism about the Patriots following their recent upset victory over the Bills.
Giants vs. Commanders, 1 p.m. ET
Pick: Cam Skattebo, Under 77.5 total rushing + receiving yards
Alex Selesnick notes that Skattebo has faced difficulties in an ineffective run game, making this a challenging matchup against a strong Commanders defense.
As the Sunday schedule progresses, other notable games include the Vikings taking on the Saints, the Broncos facing the Chargers, and the Falcons hosting the Ravens in the evening slot. Experts will continue to analyze performances and trends throughout the day, providing insights for fans and bettors.
The Monday Night Football game will feature the Bills and Rams, where Kyren Williams of the Rams is projected to exceed 89.5 total rushing and receiving yards, reflecting his growing role in the team’s offense.
As always, bettors are encouraged to engage responsibly and utilize available resources from sportsbooks, such as gaming limits and self-exclusion options, alongside helplines for support.
